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EarthX is a design-based research project that supports the integration of Earth science into high school biology, chemistry, and physics courses in Baltimore City Public Schools, while also supporting the district’s transition to three-dimensional (3D), ambitious and equitable science teaching aligned with the Next Generation Science Standards (NGSS). EarthX builds on the success of the Integrating Chemistry and Earth Science (ICE) DRK-12 project, which developed innovative chemistry course curriculum materials and PD strategies, to support Earth science integration into biology and physics course curriculum development and 3D teaching. EarthX will develop, test, and refine embedded and unit assessments for all three courses, along with providing an online system for assessment administration; real-time reporting to teachers and students; and provision of data to PD leaders, administrators, and researchers for multiple purposes. Assessments will be 3D, featuring core concepts from both Earth science and the course discipline combined with a science or engineering practice and a crosscutting concept.